Sunday, August 24, 2014

Time to end the much-told cover-up of UNSUCCESSFUL wartime penicillin and tell the untold tale of SUCCESSFUL wartime penicillin

Against about fifty previous books about wartime penicillin , I want my penicillin book to do something wildly different --- I want to celebrate success, not cover-up failure.

If the wartime deployment of penicillin was ultimately successful (and everybody seems to agree it was) what exactly did this successful  penicillin look like?

It turns out it actually was :

(a)  naturally made penicillin - not man made.

(b) and (via exports of massive amounts of American penicillin under Lend-Lease and other programs), it was made available to all in the wartime world dying from any and all diseases it could cure - not just reserved for a relatively small number of frontline Allied soldiers judged capable of returning to immediate combat, if given penicillin.

Ie , what successful wartime penicillin definitely was not, was synthesized and weaponized.


I am writing this book because I believe , 75 years after the start of wartime penicillin , it is overdue time to finally have a long, hard and brutally honest look at the actual record of the people and institutions universally regarded as the heroes of wartime penicillin.

Chief among them - by general consensus - are Fleming, Florey along with the MRC and the Ministry of Supply in Britain.

 In America : the OSRD-CMR, NRRL chief Coghill , Merck Inc and the NAS-COC .

Yet all these heroes spent the entire war stridently opposed both to (a) the immediate mass production of naturally made penicillin and (b) its wartime production in quantities sufficient for all dying for lack of it in the world .

If they be the 'heroes' of wartime penicillin , it hardly needed villains !

By contrast , institutions like the British Royal Navy, Glaxo , Pfizer , the WPB and people like Dawson , Demerec , Pulvertaft and Duhig rate a paragraph (or at best , a page or two) in even lengthy accounts of wartime penicillin.

Yet these people and institutions strongly promoted the immediate wartime mass production of naturally produced penicillin for all  - and then set out and did it - they made the successful version of wartime penicillin.

They did not advocate holding off on the wartime production of badly needed penicillin until it had been totally synthesized at commercial prices (something that hasn't happened yet).

Nor did they advocate that wartime penicillin be only used for those who were moderately injured, among the frontline Allied troops.

All these people and institutions shared one more thing in common (besides achieving the only universally popular scientific success of WWII).

They were not part of the Anglo-American medical-scientific establishment.

Thus they did not have privileged access (during the crucial years of 1944-1948) to information still labelled secret and only released - on a highly selective basis - in self-serving official histories that successfully polished the turd that was the total failure of weaponized synthetic penicillin.

It was not until 1972, with Lennard Bickel's invaluable book "RISE UP TO LIFE" , that many of the secrets of wartime penicillin began to be revealed - at least to the majority of the world that looked to British-oriented authors to explain penicillin.

Bickel was actually merely trying to boost credit to Howard Florey over that given to Alexander Fleming, but his book was just late enough to avoid the strictures of wartime secrecy and just early enough to interview many penicillin pioneers before they died.

And his account tried very hard to balance the British-oriented accounts published to date with information about lesser known but very important penicillin efforts around the world.

But Bickel , like all others to date, did not set  WPB-Pfizer-Glaxo natural penicillin in total opposition to OSRD-Merck-Oxford synthetic penicillin.

Rather, like all accounts of the atomic Manhattan Project, he sees them as being equally funded, equally ardently pushed parallel efforts towards a common (time-sensitive) goal.

But in the case of the atomic bomb , the documentary record is very clear - almost any and all ways that might help to make enough nuclear material for even a few bombs before the war's end were massively funded and whipped into a flurry of activity by General Groves .

So for example,  a trillion dollar (in 2014 dollars) gaseous diffusion production plant were built as fast as possible , before any pilot plant had even shown that particular process might work !

Even so, America only got enough weapon material for just two small bombs a scant month before Japan surrendered.

By contrast, natural penicillin's breakthrough technology ( a repeated process of selecting the best natural mutations of the penicillium mold, radiating them to produce more mutations and so on) only required a few biologists working a few months at a cost of a few thousands of dollars.

Thanks to this breakthrough, most countries outside of the USA successfully provide much of their wartime penicillin needs with a scaled up version of the primitive technology that Fleming first used - and rejected - way back in 1928 !

Only a political and moral unwillingness to create more of these primitive factories kept the UK, Canada and Australia from supplying all possible needs with scaled up 1928 technology.

It was the WPB's totally unknown OPRD , a latecomer to the penicillin effort , that quickly and cheaply made penicillin production with mutated natural penicillin such a success that we still produce all the world's antibiotics the same way to this day.

It was clear in the case of penicillin that almost everyone (outside our valiant few) from government ministers to newspaper reporters to ordinary GP doctors to Big Pharma, felt that penicillin was going to have to be first made synthetically to make enough for a wartime world and that this event was going to be quickly achieved.

(At the same time, I should say that most of the synthetic advocates generally didn't know the full extent of the intention to weaponize penicillin and that thankfully many seemed to oppose that idea when its morally repugnant nature was made clearer.)

Efforts to synthesize penicillin were fully backed by the British and American medical scientific establishment while efforts to push natural penicillin production that came from people like Cold Spring Harbour Lab chief Miloslav Demerec and Glaxo's boss Harry Jephcott were rebuffed by that same elite.

Spurred by the efforts of Dr Dawson , Dr Dante Colitti got  he Hearst media empire to rouse the Dr Moms of the world with the plight of baby Patty Malone.

Even the powerful men running the Anglo-American medical-scientific establishment (& Big Pharma) momentarily quailed before the uproar from Dr Mom , but soon they returned to pushing for perfected synthetic penicillin before seeking any all-out production.

But Big Pharma was not totally united - one man within its ranks differed - and sometimes one individual is more than enough to change a whole world.

John L Smith, boss of Pfizer, was prompted by his own Dr Mom - his wife - to connect Patty Malone to the death of his own daughter - a death that Fleming could have helped prevent if only he had promoted - rather than negating - penicillin by needle.

As an ordinary patriotic American , Smith also knew D-Day was due soon.  Unlike ordinary Americans, he also knew that only penicillin could prevent the war deaths by infection the sulfa drugs were no longer effective against.

Like General Groves on steroids, Smith whipped Pfizer employees to produce tons of penicillin - now ! - for D-Day and civilian patients.

In a surprisingly few months ( by the Spring of 1944) - Smith - thanks admittedly greatly to the timely efforts of Miloslav Demerec - had solved the world's penicillin crisis.

But the Anglo-American medical scientific establishment - as always with bureaucrats spending other peoples' money - kept pushing hard on synthetic penicillin for two more wasted years.

Their Plan B ( eventually employed) was to push the Big Half Truth that they were always fully behind natural penicillin from 1939 onward and were merely held up by the pesky penicillium spores themselves.

In fact,  the only way they could think to totally synthesize artificial penicillin was to repeatedly destroy massive amounts of natural penicillin and then examine the resulting entrails.

Thus they did in fact support the limited production of natural penicillin - all through the war - but mostly for their chemists to destroy and then analysis - not to give to any and every patient dying for lack of it.

Shamefully, academic historians have let them get away with this particular Big Half Truth ever since ....

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